The study was the first national assessment of the youth-friendly clinics (YFC) in terms of their accessibility, affordability, meeting the needs of adolescents and youth within respond to the HIV/AIDS/STD and reproductive health. The analysis of the regulatory framework, human resources and financial management provides the answer to the issue of the potential YFC sustainability, as well as reflects obstacles hindering the development of such network in Ukraine. Special attention was paid to the needs study of adolescents and youth-friendly health and social care services.